2025-26 Men’s March Madness Odds: Arizona Favored Heading Into Sweet 16

And just like that, we’re one round down.

Here’s a look at the odds for the men’s NCAA Tournament winner at DraftKings Sportsbook as of March 23.

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2025-26 Men’s NCAA Tournament winner 

Arizona: +330 (bet $10 to win $43 total)
Michigan: +340 (bet $10 to win $44 total)
Duke: +370 (bet $10 to win $37 total)
Houston: +700 (bet $10 to win $80 total)
Purdue: +1300 (bet $10 to win $140 total)
Illinois: +1400 (bet $10 to win $150 total)
Iowa State: +1600 (bet $10 to win $170 total)
UConn: +2500 (bet $10 to win $260 total)
Michigan State: +3000 (bet $10 to win $310 total)
St. John’s: +3500 (bet $10 to win $360 total)
Arkansas: +4000 (bet $10 to win $410 total)
Nebraska: +4500 (bet $10 to win $460 total)
Tennessee: +6000 (bet $10 to win $610 total)
Iowa: +12000 (bet $10 to win $1,210 total)
Alabama: +13000 (bet $10 to win $1,310 total)
Texas: +30000 (bet $10 to win $3,010 total)

Duke opened as the favorite, but after a shaky win over 16-seed Siena in the first round, the Blue Devils dropped to third, and remain there heading into the Sweet 16. In that first-round game, Duke trailed by 11 at half before outscoring Siena by 17 in the second half to secure a 71-65 win. 

Duke then went on to beat 9-seed TCU in the second round, 81-58. 

The current favorite is Arizona, which put a beatdown on 16-seed LIU in the first round, winning by 34. The Wildcats then took down 9-seed Utah State in the Round of 32, 78-66. 

Michigan remains second on the board and its odds did not shift after a 21-point win over 16-seed Howard in the first round or its 95-72 win over 9-seed Saint Louis in the second round.