Fourth of July Best MLB Betting Picks and Predictions


Jul 3, 2026; Houston, Texas, USA; Tampa Bay Rays second baseman Ben Williamson (15) tags out Houston Astros right fielder Cam Smith (11) during the fourth inning at Daikin Park. Mandatory Credit: Thomas Shea-Imagn ImagesJul 3, 2026; Houston, Texas, USA; Tampa Bay Rays second baseman Ben Williamson (15) tags out Houston Astros right fielder Cam Smith (11) during the fourth inning at Daikin Park. Mandatory Credit: Thomas Shea-Imagn Images

The Independence Day MLB card is loaded with plenty of intriguing matchups on a busy Saturday.

The Chicago Cubs (49-39) look to bounce back from Friday’s 17-1 home loss to the St. Louis Cardinals (46-39). The two NL Central rivals hook up at 8:05 p.m. ET from Wrigley Field.

Later on, the Los Angeles Dodgers (58-31) seek their third consecutive victory over the San Diego Padres (43-44) after rallying from multi-run deficits in each of the first two wins. These two teams close the night at Dodger Stadium at 10:10 p.m. ET.

We’ll break down two plays for the Saturday action. Remember to monitor the odds throughout the day, as the sides and totals market is constantly changing.

Here are the free MLB picks for Saturday, July 4. Odds Courtesy of DraftKings.

Best MLB plays today

  • Astros (-110) vs. Rays
  • Orioles/Reds Over 9 Runs

Astros (-110) vs. Rays – 7:10 p.m. ET

Tampa Bay (52-33) is riding a nine-game winning streak after holding off Houston (43-47) last night, 3-1. The Astros suffered back-to-back losses for the first time since mid-June as they try to rebound tonight with ace Hunter Brown on the mound.

Since returning from injury, Brown has allowed a total of four earned runs in three starts. The Astros have won two of three outings, capped off by an extra-innings victory at Detroit on June 28. Brown has held current Tampa Bay hitters to a .129 batting average in 31 plate appearances.

Tampa Bay’s pitching has carried them during this hot stretch, limiting opponents to three or fewer runs eight times. The Rays are 3-4 in Drew Rasmussen’s seven starts when priced at lower than -110 or in the underdog role. Let’s back the Astros to end Tampa Bay’s winning streak.

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Orioles/Reds Over 9 Runs – 7:10 p.m. ET

Baltimore blanked Cincinnati last night, 3-0 as the Reds were held to four hits. Cincinnati has seen the under hit in three of its past four home games, but look to turn things around tonight in Hunter Greene’s season debut on the mound.

The hard-throwing right-hander returns from an elbow injury, making his first start since last September. He faces a Baltimore team that cashed the over in five of its previous six games against right-handed starting pitchers prior to Friday’s low-scoring affair.

Baltimore’s Brandon Young has given up six earned runs in his past four outings, but his xERA (4.24) is over a run higher than his ERA (3.11). The Orioles own the highest hard-hit rate in MLB at 42.6, while Greene closed last season at 45% in this category, ranking in the 15th percentile.

Look for runs to be scored tonight at Great American Ballpark between the Reds and Orioles.

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